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Brexit: trial and error
Last month’s referendum result has shaken the UK’s clinical research community to the core, with anxiety levels sky high over the country’s ability to remain at the forefront of therapeutic advances.
Rob Munro

Brexit triggers uncertainty over future of research in UK
The vote in June to leave the EU could have serious implications for the NHS, clinical trials and the research and development of new pharmaceuticals in the UK.
Roberta Ellison

Causes and management of chronic pain
Nearly eight million people in the UK suffer moderate to severe chronic pain, resulting in a major impact on quality of life. This article discusses the main causes of chronic pain, the treatments available and when referral is necessary.
Ann Robinson

Guanfacine to control ADHD in children and adolescents
Guanfacine (Intuniv) is an alpha 2A agonist indicated for the treatment of attention deficit hyperactivity disorder in children and adolescents for whom stimulants are not appropriate. This article discusses the indications, monitoring requirements and clinical trial results.
Steve Chaplin

Immune checkpoint inhibitors: a new class of anticancer drug
(click here for full web article)
Over the past five years, three anticancer drugs belonging to a new class known as immune checkpoint inhibitors have become available, which are already having an impact on survival in patients with metastatic melanoma and offering promise in the treatment of other malignancies.

Pippa Corrie

Management of female-pattern hair loss
(click here for full web article)
Female-pattern hair loss is a common and distressing condition that can lead to a progressive and irreversible decline in scalp hair density if left untreated. This article discusses the causes, characteristics and management of hair loss in women.

Rebecca Mann

New from NICE
The 2015 NICE guideline on the management of type 2 diabetes recommended a role for the sodium-glucose co-transporter 2 inhibitors dapagliflozin, canagliflozin and empagliflozin only in combination with metformin.

New national Prescribing Safety Assessment for medical students
Prescribing is a complex area that new graduate doctors find challenging and up to now, assessment of medical students has been variable. However, from 1 August 2016, the new national Prescribing Safety Assessment (PSA) will become mandatory for all UK medical students.
Kate Stewart

The expanding role of pharmacists in care homes
Older people once cared for in hospitals are increasingly being moved to residential care homes to free up hospital beds and GPs are struggling to provide the medical care needed by this population. However, according to a Royal Pharmaceutical Society report, pharmacists may be ideally placed to reduce this clinical burden.
Steve Chaplin

Topical antibacterial and antiviral agents: prescribing and resistance
(click here for full web article)
This article describes the current prescribing patterns for topical antibacterial and antiviral preparations in primary care and the factors to consider when choosing a treatment, including the evidence for antimicrobial resistance.

Steve Chaplin

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