Management of female-pattern hair loss

Female-pattern hair loss is a common and distressing condition that can lead to a progressive and irreversible decline in scalp hair density if left untreated. This article discusses the causes, characteristics and management of hair loss in women.

Female-pattern hair loss is a common and distinctive form of nonscarring hair loss that affects adult women. By the age of 50 years, around 40 per cent of women will show signs of hair loss, while less than 45 per cent of women will reach the age of 80 years with a full scalp of hair.1,2 If untreated, female-pattern hair loss can lead to a progressive and irreversible decline in the density of the scalp hair. Hair is a key part of our identity and there is a social stigma attached to female bald-ness. Female-pattern hair loss can be a distressing condition that can cause significant anxiety and emotional turmoil. The GP has an important role in diagnosing hair loss and directing the patient to the appropriate treatment and resources.3

The healthy adult scalp contains about 100,000 hairs, of which 90 per cent are actively growing. They are known as ‘ana-gen’ hairs and they cannot be easily pulled out as the hair is anchored deeply into the subcutaneous fat of the scalp. Hair constantly regenerates on the scalp; each hair shaft may per-sist on the scalp for between three and seven years, before shedding and being replaced by a new hair shaft.1,4,5 The ana-gen phase lasts for most of this three to seven-year period and is followed by a ‘catagen’ phase of approximately two weeks. This is the apoptosis (programmed cell death) of the hair shaft. The three-month resting or ‘telogen’ phase then follows. Telogen hair can be pulled out relatively easily, and a normal scalp will lose around 100 telogen hairs per day.3,5,6

Beside the ratio of anagen to telogen hair on the scalp, the diameter of the hair follicles also plays a role in scalp coverage. Vellus hairs have a diameter of less than 0.03mm, compared to greater than 0.06mm for terminal hairs. Optimal scalp-hair growth and coverage of the scalp are provided by the anagen and terminal hairs.

Causes

Female-pattern hair loss has a strong genetic predisposition, with a polygenic inheritance from either or both parents.1,4,7 It has long been thought that female-pattern hair loss was the counterpart to male-pattern hair loss, and was originally referred to as female androgenic alopecia in the literature. However, the role of androgens is less proven in female-pattern hair loss compared with male-pattern hair loss.4,7

Male-pattern hair loss occurs as a consequence of the effects of dihydrotestosterone (a potent metabolite of testo­sterone) on susceptible hair follicles. Dihydrotestosterone binds to androgen receptors in hair follicles, resulting in the upregulation of genes responsible for the gradual transforma­tion of terminal hair follicles to miniaturised hair follicles.4 It was initially thought that a similar pathophysiology was respon­sible for female-pattern hair loss, as women with hyperandro­genic disorders such as polycystic ovary syndrome had features of early-onset female-pattern hair loss. However, the majority of women diagnosed with female-pattern hair loss have normal androgen levels, thus indicating that the cause is not solely related to androgen hormones.1,4,6-8

Several studies have indicated links between female-pattern hair loss and both body mass index and type 2 diabetes mellitus, which are associated with insulin resistance. Earlier puberty, fewer childbirths and use of the oral contraceptive pill are also found to be positively associated with developing female-pattern hair loss. Conversely, prolactin (which is ele­vated during breastfeeding) might be associated with decreased risk of the condition, although this has not been conclusively proven. The role of oestrogen is uncertain; female-pattern hair loss is more common after the menopause, suggesting that oestrogen has a stimulatory role in hair growth.

Signs and symptoms

Insidious, diffuse thinning of the hair on the scalp due to increased shedding or a reduction in hair volume is the most common presenting symptom (see Table 1).4 When women with noticeable signs and symptoms present to the GP, up to around 50 per cent of hair loss may have already occurred.6 There is a progressive reduction in the density of the terminal hairs, with varying distributions of hair loss. The frontal scalp and vertex of the scalp are the primary sites of involvement. The frontal hairline is usually preserved.1,4,6,7

Management_Table_1

Table 1. Key features of female-pattern hair loss and examination findings

The exact pattern of the hair loss may vary. Frontal scalp thinning produces a ‘Christmas tree-type’ pattern where the hair is parted at the midline.4 Diffuse central thinning may be the prominent feature in some women, and a large proportion of women may exhibit bitemporal thinning.2,7 The occipital scalp is usually spared and complete loss of all scalp hair is rare.9 The hair loss is not constant and women may notice accelerated phases lasting three to six months, followed by quiescence lasting six to 18 months.

Scarring, itching, soreness, scaling and inflammation of the scalp are not features of female-pattern hair loss.4

Susceptibility 

Advancing age has a strong correlation with the development of female-pattern hair loss.2 There are two peaks to the onset of hair loss: in the third and fifth decades. Early-onset female-pattern hair loss is linked to significant hair loss, especially compared with women who present with postmenopausal hair loss. Women with a family history of male-pattern hair loss are also more susceptible.

There are a number of conditions that may be associated with female-pattern hair loss, including polycystic ovary syn­drome, ovarian and adrenal tumours.4,6 A history of the six months preceding the hair loss should be explored with the patient, as significant physical or emotional stress can affect the hair follicles. This may suggest a reversible cause for the hair loss, known as telogen effluvium. This condition does not require any treatment and hair growth should return to normal within a few months.

Management

Treatment is available for female-pattern hair loss (see Table 2), though there is no cure. Patient expectations should be managed accordingly. The aim of treatment is to slow the rate of progression of hair loss, rather than promote hair regrowth. However, self-confidence may be improved by trying a different hairstyle or hair products that thicken the hair.

Management_Table_2

Table 2. Treatment of female-pattern hair loss

First-line treatment

A 2012 Cochrane review concluded that minoxidil cutaneous solution (Regaine) was effective at treating female-pattern hair loss.2 Minoxidil cutaneous solution is available in 2% and 5% strengths, in pharmacies or on private prescription.10,11 It is not available on the NHS.9 A 5% cutaneous foam preparation is now available for women and most dermatologists agree that this preparation gives greater sustained hair growth.7,11 It must be continued for at least 12 months. Women may not notice the effect until at least eight weeks into the course of treatment.7,10-12

Minoxidil is a potassium-channel opener and vasodilator, but the mechanism by which it improves female-pattern hair loss is not completely understood. One theory is that the drug length­ens the anagen phase of the hair follicles, shortens the resting phase and induces enlargement of the miniaturised follicles, and therefore the conversion of these hairs to terminal hairs.10

Potential local adverse effects of minoxidil include scalp pruritus, flaking and facial hypertrichosis.10 The low risk of scalp irritation with use of the 5% cutaneous foam formulation may be related to the absence of propylene glycol, a common irritant and a potential contact allergen.2,10

Second-line treatment

Antiandrogen therapy is recommended as a second-line treat­ment. Systemic medications that inhibit androgen production or its effects, such as spironolactone, cyproterone acetate and flutamide are available off licence if women respond poorly to monotherapy with minoxidil or have female-pattern hair loss related to hyperandrogenism.

Spironolactone is generally recommended as the first choice in second-line treatment.2,8,9 It is an aldosterone antag­onist that competitively blocks androgen receptors and weakly inhibits androgen synthesis. There is a reasonably large body of data to support the efficacy of spironolactone8 and, similar to minoxidil, it must be continued for at least six to 12 months to assess the effect on the hair.7 Flutamide and cyproterone acetate are infrequently used in the UK as there is a paucity of data available and the dosing regimens are not standardised.9

Finasteride is not recommended in women as there is currently little evidence to support its efficacy.2,10,13

Role of the GP

Women may present to the GP with varying stages of hair loss, that may or may not be accompanied by psychological distress.6 Hair loss can be difficult for women to deal with, especially younger women, and GPs should signpost patients to coun­selling services if necessary or to online resources, such as Alopecia UK14 or NHS Choices,15 for further information about female-pattern hair loss.

Clinical examination of the scalp can provide all the neces­sary information to diagnose female-pattern hair loss. Use of a dermatoscope will demonstrate the varying diameters of the hair shafts, which can then be compared to the normal follicular pattern. Key questions to ask patients are outlined in Table 3.

Management_Table_3

Table 3. Key questions to ask patients

Other causes of hair loss should be excluded, including telogen effluvium, particularly if the hair loss is very rapid. Systemic lupus erythematosus can occasionally present in this way, as can hypothyroidism, and therefore free thyroxine (T4) levels should be measured. Stored ferritin levels should also be checked, to rule out ferritin deficiency.6,7,9,16 Iron-deficiency anaemia presenting with hair loss is a separate diagnosis to female-pattern hair loss. There is little evidence to support iron deficiency accelerating female-pattern hair loss, although iron supplementation should be given in those women with female-pattern hair loss who have an incidental finding of low ferritin.16 Before confirming the diagnosis, the GP should ask about the woman’s menstrual cycle, particularly the duration and the frequency of her periods, as the hair loss may be linked to changing oestrogen levels.

Dermatological opinion is recommended before antian­drogen treatment is commenced.9 Once treatment has com­menced, women who begin a course of spironolactone should have their serum potassium levels checked around six weeks into the dosing regimen, as hyperkalaemia is a possible side-ef­fect.8 Baseline blood pressure should be checked and then routinely every six months along with a serum potassium level. Women should be counselled on the need for effective contra­ception while taking antiandrogenic medication as feminisation of a male foetus can occur if the woman conceives during a course of antiandrogenic medication.

Conclusion

Female pattern hair loss, while relatively common, can be a difficult condition to cope with. As such, the GP has a central role in supporting the patient. Women of all ages may visit the GP with varying severity of hair loss, most of whom will not have deranged androgen profiles. General practitioners should feel confident in diagnosing female pattern hair loss and initiating first-line treatment, as any further delay in care may worsen the hair loss and increase the emotional distress for the patient.

Declaration of interests

None to declare.

References
1. DermNet NZ. Female pattern hair loss. http://www.dermnetnz.org/hair-nails-sweat/female-pattern-hairloss.html [Accessed 1 May 2016]
2. Dinh QQ, Sinclair R. Female pattern hair loss: Current treatment concepts. Clin Interv Aging 2007;2(2):189–99.
3. Mubki T, et al. Evaluation and diagnosis of the hair loss patient: Part I. History and clinical examination. J Am Acad Dermatol 2014;71(3):415. e1–415.e15.
4. UpToDate. Female pattern hair loss: Pathogenesis, clinical features and diagnosis. http://www.uptodate.com/contents/femalepattern- hair-loss-androgenetic-alopecia-in-women-pathogenesis-clinical- features-and-diagnosis [Accessed 30 April 2016]
5. Shapiro J. Hair loss in women. N Eng J Med 2007;357:1620–30.
6. Grimes D, et al. Initial office evaluation of hair loss in adult women. J Nurse Pract 2011;7(6):456–62.
7. Olsen E, et al. Evaluation and treatment of male and female pattern hair loss. J Am Acad Dermatol 2005;52(2):301–11.
8. Famenini S, et al. Demographics of women with female pattern hair loss and the effectiveness of spironolactone therapy. J Am Acad Dermatol 2015;73(4):705–6.
9. NICE Clinical Knowledge Summaries. Alopecia, androgenetic – female. http://cks.nice.org.uk/alopecia-androgenetic-female#!topicsummary [Accessed 30 April 30 2016]
10. Rogers N, et al. Medical treatments for male and female pattern hair loss. J Am Acad Dermatol 2008;59(4):547–66.
11. Lucky A, et al. A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss. J Am Acad Dermatol 2004;50(4):541–53.
12. Doshi U. Effectiveness of once daily 5% minoxidil topical foam in the treatment of women with thinning hair due to female pattern hair loss (FPHL). J Am Acad Dermatol 2015;72(5, Suppl. 1):AB112.
13. Olsen E, et al. Female pattern hair loss. J Am Acad Dermatol2002;47(5):795.
14. Alopecia UK. http://www.alopeciaonline.org.uk [Accessed 1 May 2016]
15. NHS Choices. Women and hair loss: coping tips. http://www.nhs.uk/Livewell/hairloss/Pages/Womenandhairloss.aspx [Accessed 1 May 2016]
16. Olsen E, et al. Iron deficiency in female pattern hair loss, chronic telogen effluvium, and control groups. J Am Acad Dermatol 2010;63(6):991–9.

Management of female-pattern hair loss

Add yours ↓
Web design and marketing agency Leamington Spa