Management of infantile colic in practice

Colic is common in the infant population but it can be challenging to diagnose and manage in the primary care setting. In this article, Dr Kanabar discusses how to reach a diagnosis of infantile colic and provides an overview of the current treatment options and their efficacy.

Babies who cry in the first few months of life may do so for a variety of reasons including thirst, hunger, overstimulation, understimulation and, of course, when they are ill or in pain. Sometimes babies cry with no obvious cause for their discomfort or unease, and this may indicate colic – suggesting that colic is something that babies ‘do’ rather than a condition that they ‘have’.1 The prevalence of colic varies according to the definition used, but estimates range between 5% and 26% of the infant population.2,3

Diagnosis

The diagnosis of infantile colic is not particularly difficult for experienced clinicians such as consultant paediatricians or gastroenterologists, but may prove challenging in primary care or community pharmacies. With no diagnostic test, colic is a diagnosis of exclusion. Once other causes such as cow’s milk protein intolerance (CMPI), infections, constipation and gastro-oesophageal reflux have been excluded, an infant in the first four months of life who is troubled by unexplained bouts of irritability or screaming, fussiness, facial redness, clenched fists, furrowed brow and a drawing up of the knees to the chest for a period of over a week (often in the evenings) can be diagnosed as suffering from colic.4,5

A rare but potentially life-threatening differential diagnosis of a colicky baby is intestinal malrotation and therefore any infant who presents with fussiness, crying, tiredness, lethargy, fever, abdominal distension and bloody stools should be referred to hospital immediately.

Infantile colic is not considered to be a serious medical condition; however, it can occasionally lead to failure to thrive and, in extreme cases, to dehydration and electrolyte imbalance primarily due to inadequate (or inappropriate) fluid intake. More commonly, it contributes to impaired parent-child bonding and may increase the risk of non-accidental injury.6

Current treatment options

The aetiology of infantile colic is unclear, but thought to be multifactorial. Immaturity of the infant’s nervous and digestive systems are likely causes, but it is possible some infants have CMPI, altered gut microflora (low levels of bifidobacteria and lactobacilli) or increased levels of gut hormones such as ghrelin and motilin.7-9 As a result, several treatment strategies have been applied to treat colic, but only some have been successful. If CMPI or reflux oesophagitis is suspected, a time-limited therapeutic trial of a hydrolysed protein formula or anti-reflux medication is warranted.

Table 1 shows the current treatment options for infantile colic, including trial data and measured outcomes. However, there are few properly conducted randomised placebo-controlled trials, and those that exist have limited sample size.


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Table 1
. Interventions for infantile colic and their reported effects

Studies with simeticone (Infacol), one of the most commonly used colic treatments, have shown little or no effect on reduction of colic symptoms. One brief communication did suggest a benefit; however, in that study, it was not clear how colic was defined or how cases were ascertained.10

Because of its adverse side-effect profile (including apnoea, seizures and coma) the antispasmodic drug dicycloverine is contraindicated in infants under six months old.

Herbal therapies, such as using fennel seed oils, have proved beneficial in some instances.11,12 However, parents should be aware of a lack of standardisation of dosage and strength of herbal preparations (including herbal teas), and presently there are few studies of the effectiveness and safety of many herbal preparations in infants, including breast-feeding infants whose mothers take them. It is also important to remember that due to their small size and gastrointestinal immaturity, infants may respond abnormally to herbal treatments, and some treatments may even contain heavy metals such as lead, mercury or arsenic.

The idea that sugary fluids may ease infantile colic is not new either.13 A mixture of dill-flavoured sugar solution with alcohol is still sold as ‘gripe water’. It is slowly going out of fashion and, importantly, active ingredients such as sugar and alcohol are being removed from the formulation – perhaps making the compound less useful?

Lactase enzyme drops (eg Colief), which can be added to breast or formula milk, are also available to reduce lactose load, and the author’s own double-blind, randomised, placebo-controlled crossover trial to investigate the effect of lactase-treated milk on breath hydrogen excretion and crying time in infants showed some reduction in median crying time – but the study sample size was small.14

A study looking at the effect of either a hypoallergenic diet for mothers of breast-fed infants (free from milk, egg, wheat and nuts), or a casein hydrolysate milk in bottle-fed infants, was poorly designed and although pooled results of breast- and bottle-fed infants showed a significant reduction in infant distress in those on a low allergen diet compared with those on a control diet, the number of bottle-fed infants was too small to establish whether casein hydrolysate milks were of benefit compared with cow’s milk.15 A later randomised controlled trial by the same author in exclusively breastfed infants showed that a low-allergen maternal diet (excluding milk, eggs, nuts, wheat, soy and fish) significantly reduced infant crying compared with infants of mothers who continued to eat those foods.16

In another randomised double-blind trial, a hydrolysed whey formula significantly reduced crying time by 58 minutes per day (p=0.03) compared with standard cow’s milk formula.17

The effect of physical interaction with infants on colic symptoms has also been investigated. In one study, advice to increase infant carrying showed no benefit compared with normal infant care;18 conversely, reduced stimulation has been shown to have a beneficial effect.19 Another study showed that counselling parents to respond to their babies’ cries by feeding, holding, offering a pacifier, stimulating or putting the baby down to sleep decreased the duration of crying by up to an hour per day (p=0.05) compared with milk substitution (soya or cow’s milk substituted with casein hydrolysate).20

A study comparing infant massage (performed three times a day using olive oil) versus a crib vibrator device over a four-week period found no significant difference between the two interventions, and it is also possible that massage may overstimulate a colicky infant.21 However, a randomised controlled Danish study did show benefit from spinal manipulation (chiropractic therapy for two weeks) versus two weeks of daily treatment with simeticone. This trial found that spinal manipulation significantly reduced crying time compared with simeticone (mean reduction in crying on days four to seven: 2.4 hours with spinal manipulation versus 1.0 hours with simeticone; p=0.04).22 However, the study was not blinded to treatment allocation, and a colic diary was kept.

Based upon the hypothesis that aberrant intestinal microflora may be responsible for intestinal dysfunction and excess gas production, the use of probiotics in infantile colic is gaining considerable interest. A randomised controlled trial showed that once-daily administration of Lactobacillus reuteri DSM 17938 oral drops to breastfed infants is well tolerated and improves symptoms of infantile colic compared with simeticone or placebo.23


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Figure 1
. Management of infantile colic

Conclusion

Infantile colic is a common problem, and colicky crying babies can cause stress, frustration and anxiety for families. Many parents report how difficult it is to pacify their babies and this makes them feel helpless and guilty about their supposed lack of skill. Both casein and whey hydrolysed formulas have been used in infantile colic trials with limited success. If an infant is thriving on standard formula or breast milk, there is no need to change milks, unless of course there is strong evidence of CMPI, in which case the advice would be to change to a hypoallergenic formula, or for a breast-feeding mother to alter her diet. If the infant has faltering growth, then it is imperative to refer these babies for urgent investigation and not give them a ‘colic’ label without full investigation.

There is insufficient clinical evidence to advocate one particular treatment option over another and the management flowchart in Figure 1 should assist healthcare professionals in managing this complex condition, as many parents will have struggled between the various interventions.

Clinical trials are currently underway with a neurokinin 2-receptor antagonist, which reduces intestinal motility and may offer a new approach to therapy.

Support, encouragement and practical advice is important, as is asking, where possible, other family members or friends to take care of the child for brief periods to allow parents to refresh themselves.24 It is important to stress to families that colic is a temporary problem, that it is not their fault, and that it can generally be managed nonmedically, using manoeuvres such as gentle rhythmic rocking in a quiet environment, or even a car ride. Perhaps it is also worth suggesting to families that it is a sign that their baby is normal and vigorous and their infant’s crying may be due to underlying changes in the nervous system and how it modulates their baby’s behaviour.

The above strategies should help busy clinicians, nurses or health visitors to manage a stressful period of child development, as well as help prevent any serious outcomes of this generally benign and self-limiting condition. They should also help reduce the numbers of infants presenting to accident and emergency and other secondary care services.

Declarations of interests

None to declare.

Dr Kanabar is a consultant paediatrician at Evelina Children’s Hospital, London

References

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3. Lucassen PLBJ, et al. Systematic review of the occurrence of infantile colic in the community. Arch Dis Child 2001;84:398–403.
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19. McKenzie S. Troublesome crying in infants: effect of advice to reduce stimulation. Arch Dis Child 1991:66:1416–20.
20. Taubman B. Parental counselling compared with elimination of cow’s milk or soy milk protein for the treatment of infant colic syndrome: a randomized trial. Pediatrics 1988;81(6):756–61.
21. Huhtala V, et al. Infant massage compared with crib vibrator in the treatment of colicky infants. Pediatrics 2000;105:e84.
22. Wiberg JM, et al. The short-term effect of spinal manipulation in the treatment of infantile colic. J Manipulative Physiol Ther 1999;22:517–22.
23. Savino F, et al. Preventive effects of oral probiotic on infantile colic: a prospective, randomised, blinded controlled trial using Lactobacillus reuteri DSM 17938. Benef Microbes 2015;6:245–51.
24. Wolke D, et al. Excessive infant crying: a controlled study of mothers helping mothers. Pediatrics 1994:94:322–32.

Management of infantile colic in practice

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