Articles: 25.12 19 June 2014

A sore throat, fever and rash

A nine-year-old boy, with no significant past medical history, presented to his GP with a two-day history of fever, malaise, rash and sore throat. His symptoms had begun abruptly with fever of 39.5°C and sore throat.
A sore throat fever and rash

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Affording expensive new drugs

Often lost in the indignant protests over the NHS not funding the latest ‘wonder drug’ is that such drugs can be eyewateringly expensive. The latest furore has been over NICE’s provisional determination on Kadcyla (trastuzumab emtansine) – the view from NICE was that this drug …

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Depression: current approaches to assessment and treatment

Depression is common and concerns persist regarding choice of effective treatments. Our Drug review discusses aspects of recommended management and changes in classification, followed by sources of further information and an analysis of the prescription data.
Depression current approaches to assessment and treatment

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Erectile dysfunction: assessment and management in primary care

PDE5 inhibitors are the firstline treatment for erectile dysfunction and allow management of ED in general practice. Here, the authors outline the causes, assessment and treatment options for this distressing condition.
Erectile dysfunction assessment and management in primary care

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Improvements suggested by Enthoven and Maynard

In our series on the history of prescribing policy, Dr Darrin Baines traces how successive governments have attempted to curb drug costs. Here, he describes the proposals suggested by Alain Enthoven and Alan Maynard in the 1980s.
Improvements suggested by Enthoven and Maynard

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Nalmefene: first drug for reducing alcohol consumption

Nalmefene (Selincro) is the first drug approved for the reduction of alcohol consumption. In our New products review, Steve Chaplin presents the data relating to its efficacy and adverse events, and Professor Jonathan Chick discusses its place in therapy.
Nalmefene first drug for reducing alcohol consumption

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New anticoagulants vs warfarin in AF: no clear winner

In this meta-analysis, newer anticoagulants appear to be slightly more effective than warfarin in the short term (two years) in preventing strokes of all kinds in patients with atrial fibrillation (AF). However, they are no more effective than warfarin in preventing ischaemic strokes and they …

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New from NICE

In 2009, NICE recommended ustekinumab (Stelara), a monoclonal antibody against interleukins 12 and 23, as an option for the treatment of moderate to severe plaque psoriasis. In Technology Appraisal 313, it has now declined to recommend its use for active psoriatic arthritis.
New from NICE 19 …

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