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First evidence of clinical trial efficacy for COVID-19 vaccine

Pfizer and BioNTech have announced preliminary phase 3 trial results of their mRNA-based SARS-CoV-2 vaccine, BNT162b2. According to the first interim efficacy...Read more

NICE recommends liraglutide for managing obesity

In a final appraisal determination, NICE has recommended liraglutide (Saxenda) for managing obesity in adults, alongside a reduced calorie diet and increased...Read more

New EMA marketing authorisation recommendations

At its latest meeting in October, the EMA’s Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion on nine new medicines (excluding...Read more

NICE and SIGN developing Long COVID guideline

NICE and the Scottish Intercollegiate Guidelines Network (SIGN) have announced that they are working with the RCGP to co-develop a new rapid COVID-19 guideline...Read more

New guidance on naldemedine for opioid-induced constipation

NICE has published new technology appraisal guidance (TA651) on the use of naldemedine (Rizmoic) for the treatment of opioid-induced constipation. NICE...Read more

Featured Articles

The importance of measuring biomarkers in asthma
Recent studies confirm that one size of asthma management does not fit all and that patients differ in their patterns of inflammation and responses to therapy. This article discusses how measuring biomarkers can allow clinicians to tailor treatment effectively, and how research on the relationship between parasites and the immune system is providing insights into potential new therapies.
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Deprescribing antihypertensives in patients with multimorbidity
Deprescribing preventative medications such as antihypertensives may reduce adverse events in some older adults, leading to improved quality of life. The Optimising Treatment for Mild Systolic Hypertension in the Elderly (OPTIMISE) trial examined the safety and efficacy of antihypertensive deprescribing in older patients taking more than one treatment for hypertension. This article discusses the findings of the study and their implications for clinical practice.
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Systemic anticancer therapies and the role of primary care
Supporting cancer patients receiving systemic cancer therapies requires a multidisciplinary approach, and primary care plays a key role in identifying and managing the physical effects of treatment, providing psychosocial support and arranging specialist review. This article discusses the management of patients receiving systemic cancer therapies from a primary care perspective.
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