Contents: March 2016 27.03

Adult GORD: advances and challenges in management
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Gastro-oesophageal reflux disease (GORD) is a common and often chronic condition that is associated with poor quality of life and significant complications. This review provides a summary of the pathophysiology, assessment and current management of GORD in adults.
Kumar Basu

Antimicrobial resistance: are we doing enough?
UK government initiatives and new research seek to tackle the problem of antimicrobial resistance, but are these strategies enough to have an impact on this looming global catastrophe?
Danny Buckland

Direct-acting antiviral drugs for the treatment of hepatitis C
New direct-acting antiviral drug treatments for hepatitis C are more effective, easier to take and have fewer side-effects than older treatments. New technology appraisals from NICE have recommended specific combinations of these treatments for different patient groups with hepatitis C, meaning that more patients will now have access to these drugs on the NHS.
Kate Stewart

Improving recognition and management of coeliac disease
Coeliac disease is a prevalent condition, but it is currently under-recognised and undertreated in the UK. The new NICE guidance published in September aims to address these issues, offering advice on who to test, how to manage the condition and what support to offer patients.
Joy Ogden

Latest guidance updates
New from NICE

Pre-exposure prophylaxis to reduce HIV infection in the UK
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Recent research has estimated that pre-exposure prophylaxis (PrEP) using the antiretroviral therapy Truvada (tenofovir disoproxil/emtricitabine) in men who have sex with men could prevent thousands of new HIV infections in the UK by the end of the decade. However, the treatment has not yet been made available on the NHS for this indication.
Kate Stewart

Shared decision-making and the use of patient decision aids
As part of our series on the NICE Medicines Optimisation guideline, this article discusses the section of the guidance concerning shared decisionmaking and the use of patient decision aids.
Ben Rehman

The impact of meningitis vaccines and their future role
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The success of the meningococcal group A (MenA) vaccination in the African meningitis belt, public support for the extension of the MenB vaccination in the UK and the importance of vaccination in the fight against antimicrobial resistance all endorse the need for additional meningitis vaccines in the future.
Mark Greener

Vortioxetine for the treatment of major depression in adults
Vortioxetine (Brintellix) is a new antidepressant recently recommended by NICE as third-line therapy for the treatment of major depressive episodes in adults. This article describes the drug’s properties, clinical trial evidence for its efficacy and its adverse effects.
Steve Chaplin

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