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Enstilar cutaneous foam for the treatment of psoriasis vulgaris
Enstilar (calcipotriol and betamethasone) is a new cutaneous foam formulation recently launched for the treatment of psoriasis vulgaris (plaque psoriasis) in adults. This article discusses its place in therapy, efficacy and adverse effects.
Steve Chaplin

New from NICE
NG54: Mental health problems in people with learning disabilities: prevention, assessment and management

NICE guidance on the diagnosis and early management of sepsis
In July, NICE issued a guideline on the recognition, diagnosis and early management of sepsis, in response to the publication of evidence showing significant shortcomings in care. This article summarises the main recommendations of the new guidance.
Steve Chaplin

Optimising care for people with motor neurone disease
(click here to view full web article)
The prospects for patients with a diagnosis of motor neurone disease are bleak; the disease progresses rapidly, life expectancy is low and there is currently no cure. However, recent initiatives are helping to improve patients’ quality of life through earlier diagnosis and optimising care.
Danny Buckland

Recent advances in the management of cystic fibrosis
(click here to view full web article)
More effective management programmes and treatments mean that life expectancy for people with cystic fibrosis is improving. This article examines the expanding role of primary care in the management of cystic fibrosis and discusses the availability of new treatments that target the underlying cause of the disease.
Danny Buckland

Sacubitril/valsartan for chronic heart failure: its future potential
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Sacubitril/valsartan (Entresto), a combined neprilysin inhibitor/angiotensin II-receptor antagonist for the treatment of chronic heart failure with reduced ejection fraction, was launched in the UK in January. The phase 3 clinical trial PARADIGM-HF established its efficacy in chronic heart failure but what is its future place in therapy, according to the latest guidelines and research?
Steve Chaplin

Treatment of polycystic ovarian syndrome in primary care
Polycystic ovarian syndrome (PCOS) is a common and complex syndrome that presents with a wide spectrum of clinical symptoms and is also associated with several other serious conditions. This article reviews the recommended management of PCOS and its associated symptoms in primary care and discusses when referral is necessary.
Anna Graham and Haitham Hamoda

Trump victory good news for pharma profits
In September last year, flamboyant US entrepreneur and hedge fund manager Martin Shkreli unleashed a torrent of outrage and personal abuse when his drug company Turing raised the price of the ancient antiparasitic pyrimethamine from US$13.50 to US$750.
Rob Munro

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