Large variation in management of nausea and vomiting in pregnancy

An observational study from researchers at the University of Warwick focusing on the health economy within one NHS CCG indicates that there is currently considerable variation in the management of nausea and vomiting in pregnancy in general practice and the financial impact is high (Br …

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Missed GP appointments cost NHS England £216 million annually

According to NHS England, over 15 million general practice appointments (including GP, nurse and other practice staff sessions) are missed each year in England through patients failing to attend or inform the practice, representing 5% of all appointments. About 7.2 million of these appointments are …

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EMA concludes that omega-3 fatty acids not effective for secondary prevention

Following a review of all the available data, the EMA’s Committee for Medicinal Products for Human Use (CHMP) has concluded that omega-3 fatty acid medications are not effective for the secondary prevention of cardiovascular disease following myocardial infarction (MI).
Omega-3 fatty acid medicines contain the fatty …

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National Osteoporosis Society publishes new guidance on vitamin D

The National Osteoporosis Society has published a clinical guideline for health professionals on vitamin D prescribing and the management of bone heath in adults. The guideline provides up-to-date advice from clinicians and scientists with expertise in vitamin D and osteoporosis, using evidence from the 2010 …

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NICE recommends axicabtagene ciloleucel, another CAR-T cell therapy

In a final appraisal determination, NICE has recommended the CAR-T cell therapy axicabtagene ciloleucel (Yescarta) within the Cancer Drugs Fund for certain patients with non-Hodgkin lymphoma.
NICE recommends axicabtagene ciloleucel within its marketing authorisation, ie for adult patients with relapsed or refractory diffuse large B cell lymphoma …

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NICE publishes antimicrobial prescribing guidance for COPD

NICE has published new guidance on prescribing antibiotics for acute exacerbations of chronic obstructive pulmonary disease (COPD) (NG114).
An acute exacerbation of COPD is a sustained worsening of symptoms from a person’s stable disease state. NICE notes that a range of factors can trigger a COPD …

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Mental health disorders on the rise in young people in England

One in eight (12.8%) children and young people aged 5–19 years in England has a mental health disorder, according to a recent survey carried out for NHS Digital by the National Centre for Social Research, the Office for National Statistics and Youth in Mind.
The 2017 …

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NICE recommends tofacitinib for moderate to severe ulcerative colitis

In final technology appraisal guidance (TA547), NICE has recommended tofacitinib (Xeljanz) as an option for the treatment of moderately to severely active ulcerative colitis in adults when conventional therapy or a biological agent cannot be tolerated, or if the disease has responded inadequately or lost …

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Non-melanoma skin cancer risk with hydrochlorothiazide

In a recent drug safety update, the Medicines and Healthcare products Regulatory Agency (MHRA) has highlighted the risk of non-melanoma skin cancer with hydrochlorothiazide, particularly with long-term use.
The MHRA notes that recent studies have shown that exposure to increasing cumulative doses of hydrochlorothiazide is associated …

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Steep rise in measles cases in England

Public Health England (PHE) has reported a steep rise in measles cases in England in 2018. Between 1 January and 31 October this year, there were already 913 laboratory-confirmed cases, compared with 259 cases throughout 2017. PHE said that the rise was associated with measles …

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