NICE and SIGN developing Long COVID guideline

NICE and the Scottish Intercollegiate Guidelines Network (SIGN) have announced that they are working with the RCGP to co-develop a new rapid COVID-19 guideline addressing Long COVID.
Long COVID is a condition that describes persistent symptoms of COVID-19 following on from the acute infection, regardless of …

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New guidance on naldemedine for opioid-induced constipation

NICE has published new technology appraisal guidance (TA651) on the use of naldemedine (Rizmoic) for the treatment of opioid-induced constipation.
NICE recommends naldemedine as an option for treating opioid-induced constipation in adults who have had laxative treatment (ie according to the terms of its marketing authorisation). …

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EMA conducts rolling review of two COVID-19 vaccines

The EMA’s Committee for Medicinal Products for Human Use (CHMP) has started rolling review of two COVID-19 vaccines currently in clinical trials.
A rolling review is used to speed up the assessment of a promising new medicine or vaccine during a public health emergency. In this …

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New marketing authorisation recommendations from the CHMP

The EMA’s Committee for Medicinal Products for Human Use (CHMP) has recommended four new medicines (not including generics or biosimilars) for approval at its September meeting.
It has granted a positive opinion for Exparel, a new formulation of bupivacaine (liposome injectable suspension) for the treatment of …

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Corticosteroids reduce mortality in critically ill patients with COVID-19

A meta-analysis by the WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working group has provided more evidence that systemic corticosteroids can reduce mortality in critically ill patients with COVID-19 (JAMA 2 September 2020; DOI: doi:10.1001/jama.2020.17023).
The prospective meta-analysis of seven randomised trials from 12 countries …

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New guidance on rehabilitation for complex psychosis

NICE has published guidance on mental health rehabilitation for adults with complex psychosis (NG181). The aim is to promote a positive approach to long-term recovery and to ensure that people have access to help when they need it.
NICE defines complex psychosis as a primary diagnosis …

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NICE publishes new guideline on perioperative care

NICE has published a new guideline on perioperative care in adults undergoing elective or emergency surgery, including dental surgery (NG180). The guidance covers all stages of perioperative care from booking in to post-discharge, including recommendations on preparation for surgery, safety during surgery and pain relief …

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Oxford’s COVID-19 vaccine induces strong immune response

Oxford University’s ChAdOx1 nCoV-19 vaccine against COVID-19 induces a strong immune response, according to interim results of a UK phase 1/2 trial, recently published The Lancet. The trial also indicates that there are no early serious safety concerns, showing a similar safety profile to similar …

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NICE draft guidance advises against common painkillers for chronic primary pain

In new draft guidance for consultation, NICE has recommended that several commonly used painkillers should not be prescribed for chronic primary pain.
The draft guideline, Chronic Pain in Over 16s: Assessment and Management, includes recommendations on the pharmacological management of chronic primary pain, which it defines …

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EC grants conditional marketing authorisation for remdesivir

The European Commission has granted a conditional marketing authorisation for remdesivir (Veklury), for the treatment of COVID-19 in adults and adolescents from 12 years of age (and body weight at least 40kg) with pneumonia who require supplemental oxygen.
The European Commission’s decision was made just over …

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