Articles: 29.06 June 2018

Antidepressants – new answers, new questions

For years there has been widespread scepticism over the efficacy of antidepressants. The publication of a recent review of antidepressants found they have significant benefit for individuals with moderate to severe depression; however, comprehensive psychological services must not be replaced with boxes of tablets and capsules

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Weighing up the benefits of antidepressant drugs

The systematic review and network meta-analysis of the efficacy of 21 antidepressants by Andrea Cipriani and colleagues has been hailed as a major contribution to the body of evidence that supports the use of these drugs in managing major depressive disorder. This article summarises the review’s findings and their implications for practice

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Mood instability versus bipolar disorder: what to look for

It is important to differentiate between the various disorders that feature mood instability because this has significant implications for management. In this article, the authors discuss the differential diagnosis of bipolar disorder and other types of mood instability and the current recommended treatment options

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Diagnosis and management of polymyalgia rheumatica

Polymyalgia rheumatica (PMR) can be a disabling condition, but the diagnosis is often delayed because many other conditions can mimic it. This article describes the recommended investigations and treatments for PMR, and discusses the GP’s role in management

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Precision diabetes treatment comes a step closer

The recently published Lancet Diabetes and Endocrinology paper that identifies five subtypes of adult-onset diabetes associated with differing risk of complications has sparked new debate on the classification of diabetes and may help bring precision medicine a step closer

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Guselkumab for the treatment of plaque psoriasis

Guselkumab (Tremfya) is a monoclonal antibody against interleukin-23 for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. This article discusses its efficacy, side-effects and place in therapy

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New guidelines on managing generalised pruritus

The British Association of Dermatologists (BAD) published new evidence-based guidelines on the management of generalised pruritus (itch) in adults in 2018. This article provides an overview of the new guidance and its implications for primary care

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